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It was the discovery of melatonin synthesis in endocrine organs, particularly the pineal gland, neural structures, as well as immunocompetent cells such as T lymphocytes, NK cells, as well as mast cells that triggered the new approaches to the unifield signal regulation of homeostasis, which, at the turn of the 21st century, result in the development of a brand-new important biomedical technique - neuroimmunoendocrinology.
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