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It was the discovery of melatonin synthesis in endocrine body organs, particularly the pineal gland, neural frameworks, and immunocompetent cells such as T lymphocytes, NK cells, and mast cells that activated the new strategies to the unifield signal policy of homeostasis, which, at the turn of the 21st century, lead to the creation of a brand-new essential biomedical discipline - neuroimmunoendocrinology.
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